Communication

A Programmable DNA-Based Molecular Valve for Colloidal Mesoporous Silica†

  1. Axel Schlossbauer1,
  2. Simon Warncke2,
  3. Philipp M. E. Gramlich Dr.1,
  4. Johann Kecht Dr.1,
  5. Antonio Manetto Dr.2,
  6. Thomas Carell Prof. Dr.1,
  7. Thomas Bein Prof. Dr.1

Article first published online: 10 JUN 2010

DOI: 10.1002/anie.201000827

Issue

Angewandte Chemie International Edition

Angewandte Chemie International Edition

Volume 49, Issue 28, pages 4734–4737, June 28, 2010

Additional Information

How to Cite

Schlossbauer, A., Warncke, S., Gramlich, Philipp M. E., Kecht, J., Manetto, A., Carell, T. and Bein, T. (2010), A Programmable DNA-Based Molecular Valve for Colloidal Mesoporous Silica. Angew. Chem. Int. Ed., 49: 4734–4737. doi: 10.1002/anie.201000827

Author Information

  1. 1

    Department of Chemistry and Center for NanoScience (CeNS), University of Munich (LMU), Butenandtstrasse 5–13, Gerhard Ertl Building, 81377 München, (Germany), Fax: (+49) 89-2180-77622 http://bein.cup.uni-muenchen.de

  2. 2

    Baseclick GmbH, Bahnhofstrasse 9–15, 82327 Tutzing (Germany)

  1. †

    This work was funded by the Deutsche Forschungsgemeinschaft (DFG) through the cluster “Nanosystems Initiative Munich”(NIM), SFB 486, and SFB 749. We thank Bastian Rühle for the 3D artwork, Markus Döblinger for TEM measurements, and Tina Reuther for nitrogen sorption measurements.

Publication History

  1. Issue published online: 21 JUN 2010
  2. Article first published online: 10 JUN 2010
  3. Manuscript Received: 10 FEB 2010

Funded by

  • Deutsche Forschungsgemeinschaft (DFG)

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

View Full Article with Supporting Information (HTML) Get PDF (517K)

Keywords:

  • click chemistry;
  • colloids;
  • DNA;
  • host–guest systems;
  • nanotechnology
Thumbnail image of graphical abstract

Letting off steam: A temperature-controlled valve system permits the targeted release of guest fluorescein molecules from the pores of colloidal mesoporous silica particles. The pore-opening temperature is dependent on the length of double-stranded DNA linkers. Avidin proteins that are joined to the DNA by a biotin modification act as the molecular valve at the exits to the pores.

View Full Article with Supporting Information (HTML) Get PDF (517K)