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A Programmable DNA-Based Molecular Valve for Colloidal Mesoporous Silica


  • This work was funded by the Deutsche Forschungsgemeinschaft (DFG) through the cluster “Nanosystems Initiative Munich”(NIM), SFB 486, and SFB 749. We thank Bastian Rühle for the 3D artwork, Markus Döblinger for TEM measurements, and Tina Reuther for nitrogen sorption measurements.


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Letting off steam: A temperature-controlled valve system permits the targeted release of guest fluorescein molecules from the pores of colloidal mesoporous silica particles. The pore-opening temperature is dependent on the length of double-stranded DNA linkers. Avidin proteins that are joined to the DNA by a biotin modification act as the molecular valve at the exits to the pores.

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