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Colorimetric Logic Gates Based on Supramolecular DNAzyme Structures

Authors

  • Sai Bi Dr.,

    1. Key Laboratory of Eco-chemical Engineering, Ministry of Education, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042 (P.R. China), Fax: (+86)-532-8402-2750
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  • Yameng Yan,

    1. Key Laboratory of Eco-chemical Engineering, Ministry of Education, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042 (P.R. China), Fax: (+86)-532-8402-2750
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  • Shuangyuan Hao,

    1. Key Laboratory of Eco-chemical Engineering, Ministry of Education, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042 (P.R. China), Fax: (+86)-532-8402-2750
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  • Shusheng Zhang Prof. Dr.

    1. Key Laboratory of Eco-chemical Engineering, Ministry of Education, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042 (P.R. China), Fax: (+86)-532-8402-2750
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  • This work was supported by the Excellent Young Scientists Foundation of Shandong Province (JQ200805), the University Doctoral Foundation of the Ministry of Education (200804260001), and the National Basic Research Program of China (2010CB732404).

Abstract

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It′s logical! A set of DNAzyme-based Boolean logic gates consists of a series of supramolecular structures (see picture). Two metal ions (Mg2+ and Pb2+) act as inputs and gold nanoparticle (AuNP)/DNA probes as output reporters for colorimetric detection. Fast performance of the logic system at ambient temperature is achieved.

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