Asymmetric, Protecting-Group-Free Total Synthesis of (−)-Englerin A

Authors

  • Qianghui Zhou,

    1. State Key Laboratory of Bioorganic & Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032 (China), Fax: (+86) 21-6416-6128
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  • Xiaofei Chen,

    1. State Key Laboratory of Bioorganic & Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032 (China), Fax: (+86) 21-6416-6128
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  • Dawei Ma Prof. Dr.

    1. State Key Laboratory of Bioorganic & Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032 (China), Fax: (+86) 21-6416-6128
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  • We are grateful to National Basic Research Program of China (973 Program, grant 2010CB833200), Chinese Academy of Sciences and the National Natural Science Foundation of China (grant 20632050 & 20921091) for their financial support.

Abstract

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The golden touch: Total synthesis of natural (−)-englerin A from (R)-citronellal has been achieved using a gold-catalyzed cyclization as the key step (see scheme). No protecting-group manipulations were required in the synthetic sequence.

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