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Microscopic Mechanism of Specific Peptide Adhesion to Semiconductor Substrates

Authors

  • Dr. Michael Bachmann,

    1. Institut für Festkörperforschung, Theorie II, Forschungszentrum Jülich (Germany)
    2. Computational Biology & Biological Physics, Department of Astronomy and Theoretical Physics, Lund University (Sweden)
    3. Institut für Theoretische Physik, Universität Leipzig (Germany)
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  • Dr. Karsten Goede,

    Corresponding author
    1. Institut für Experimentelle Physik II, Universität Leipzig, Linnéstrasse 5, 04103 Leipzig (Germany), Fax: (+49) 341-9732668
    • Institut für Experimentelle Physik II, Universität Leipzig, Linnéstrasse 5, 04103 Leipzig (Germany), Fax: (+49) 341-9732668
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  • Prof. Annette G. Beck-Sickinger,

    1. Institut für Biochemie, Universität Leipzig (Germany)
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  • Prof. Marius Grundmann,

    1. Institut für Experimentelle Physik II, Universität Leipzig, Linnéstrasse 5, 04103 Leipzig (Germany), Fax: (+49) 341-9732668
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  • Prof. Anders Irbäck,

    1. Computational Biology & Biological Physics, Department of Astronomy and Theoretical Physics, Lund University (Sweden)
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  • Prof. Wolfhard Janke

    1. Institut für Theoretische Physik, Universität Leipzig (Germany)
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  • We thank Simon Mitternacht for helpful discussions regarding the peptide model and C. Dammann for peptide synthesis and purification. M.B. thanks the DFG (German Science Foundation) and the Wenner-Gren Foundation (Sweden) for research fellowships, and the German–Israeli “Umbrella” program for support. M.B., A.I., and W.J. are grateful for support by the German–Swedish DAAD–STINT Personnel Exchange Programme. This work is also partially funded by the DFG under Grant No. JA 483/24-1/2/3, the Leipzig Graduate School of Excellence “BuildMoNa”, TR 67A4, and the German–French DFH-UFA PhD College under Grant No. CDFA-02-07. Supercomputer time at the John von Neumann Institute for Computing (NIC), Forschungszentrum Jülich, is acknowledged (Grant Nos. hlz11, jiff39, and jiff43).

Abstract

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On the surface of it: Experimental and computational analyses for a hybrid peptide–substrate system showed that changing the position of a proline residue in synthetic peptides changes their adsorption onto semiconductors substantially and predictably (see picture with a Si(100) surface). Such information is essential for the formation of novel peptide–solid interfaces for nanotechnological applications.

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