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Keywords:

  • arenes;
  • C[BOND]O activation;
  • cross-coupling;
  • directed ortho-metalation;
  • domino reactions
Thumbnail image of graphical abstract

Twice as good: This highlight illustrates the development of new protocols for the efficient synthesis of polysubstituted arenes. The dual role of carbamate and sulfamate substituents as directing and leaving groups has been exploited in efficient reaction sequences of directed ortho-metalation and chemoselective nickel-catalyzed Suzuki–Miyaura cross-coupling reactions (see structure).