Colorimetric Detection of Glucose in Rat Brain Using Gold Nanoparticles

Authors

  • Ying Jiang,

    1. Beijing National Laboratory for Molecular Sciences, Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, The Chinese Academy of Sciences, Beijing 100080 (China), Fax: (+86) 10-6255-9373
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  • Hong Zhao Dr.,

    1. Graduate School of The Chinese Academy of Science, Beijing 100049 (China)
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  • Yuqing Lin Dr.,

    1. Beijing National Laboratory for Molecular Sciences, Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, The Chinese Academy of Sciences, Beijing 100080 (China), Fax: (+86) 10-6255-9373
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  • Ningning Zhu Dr.,

    1. Beijing National Laboratory for Molecular Sciences, Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, The Chinese Academy of Sciences, Beijing 100080 (China), Fax: (+86) 10-6255-9373
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  • Yurong Ma,

    1. Graduate School of The Chinese Academy of Science, Beijing 100049 (China)
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  • Lanqun Mao Prof.

    1. Beijing National Laboratory for Molecular Sciences, Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, The Chinese Academy of Sciences, Beijing 100080 (China), Fax: (+86) 10-6255-9373
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  • This research was financially supported by the NSF of China (Grant Nos. 20975104, 20935005, 20625515, 90813032), the National Basic Research Program of China (973 program, 2007CB935603 and 2010CB33502), and The Chinese Academy of Sciences (KJCX2-YW-W25 and KJCX2-YW-H11). Y.L. acknowledges financial support from the NSF of China (20905071).

Abstract

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A gold-based assay: By taking advantage of the unique optical properties of gold nanoparticles (AuNPs) and the cascade reactions of glucose, a simple but effective method has been successfully developed for the direct colorimetric visualization of glucose in the rat brain. GOD=glucose oxidase.

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