Probing the Kinetics of Short-Distance Drug Release from Nanocarriers to Nanoacceptors


  • We thank the Ministry of Education, Singapore (ARC 13/09) for financial support.


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Quick release: Polymer-coated gold nanoparticles (AuNPs) are used as nanocarriers and nanoscale acceptors are used to represent proteins and lipid membranes in a model drug-delivery system. The fluorescence of a drug is quenched in the vicinity of the AuNPs but reemerges upon its release (see picture). The critical role of nanoacceptors in facilitating drug release is demonstrated.