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Metal-Free Catalytic Boration at the β-Position of α,β-Unsaturated Compounds: A Challenging Asymmetric Induction


  • We thank the MEC for funding (CTQ2010-16226BQU and Consolider-Ingenio 2010 CSD-0003). A.B. thanks Generalitat Catalunya for a FI grant. We thank Solvias and DSM for the gift of ligands, and Dra. Rosa Ras for her valuable help on the chiral HPLC and GC measurements.


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Enantiomerically enriched secondary organoboronates containing β-carbonyl functional groups have been prepared using an unprecedented organocatalytic system (see scheme). The use of chiral tertiary phosphorus compounds induced ee values of up to 95 % in the absence of transition metals.