MCR: multicomponent reaction. We thank Dr. Ulli Rothweiler for fruitful discussion. This work was supported by the NIH (grant 1R21M087617-01 to A.D.) and the Deutsche Krebshilfe (grant 108354 to T.H.) and is part of an NCI-RAND program. We thank Haixia Liu for the synthesis of PB3.
Robust Generation of Lead Compounds for Protein–Protein Interactions by Computational and MCR Chemistry: p53/Hdm2 Antagonists†
Article first published online: 23 JUN 2010
Copyright © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 49, Issue 31, pages 5352–5356, July 19, 2010
How to Cite
Czarna, A., Beck, B., Srivastava, S., Popowicz, Grzegorz M., Wolf, S., Huang, Y., Bista, M., Holak, Tad A. and Dömling, A. (2010), Robust Generation of Lead Compounds for Protein–Protein Interactions by Computational and MCR Chemistry: p53/Hdm2 Antagonists. Angew. Chem. Int. Ed., 49: 5352–5356. doi: 10.1002/anie.201001343
- Issue published online: 16 JUL 2010
- Article first published online: 23 JUN 2010
- Manuscript Revised: 4 MAY 2010
- Manuscript Received: 5 MAR 2010
- NIH. Grant Number: 1R21M087617-01
- Deutsche Krebshilfe. Grant Number: 108354
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