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A Graphene Oxide Based Immuno-biosensor for Pathogen Detection

Authors

  • Jae Hwan Jung,

    1. Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology (KAIST), 373-1, Guseong-dong, Yuseong-gu, Daejeon, 305-701 (Republic of Korea), Fax: (+82) 42-350-3910
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  • Doo Sung Cheon Dr.,

    1. Division of Enteric and Hepatitis Viruses, Korea Centers for Disease Control and Prevention (KCDC), 5, Nokbun-dong, Eunpyung-gu, Seoul, 122-701 (Republic of Korea)
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  • Fei Liu,

    1. Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology (KAIST), 373-1, Guseong-dong, Yuseong-gu, Daejeon, 305-701 (Republic of Korea), Fax: (+82) 42-350-3910
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  • Kang Bum Lee,

    1. Division of Enteric and Hepatitis Viruses, Korea Centers for Disease Control and Prevention (KCDC), 5, Nokbun-dong, Eunpyung-gu, Seoul, 122-701 (Republic of Korea)
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  • Tae Seok Seo Prof.

    1. Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology (KAIST), 373-1, Guseong-dong, Yuseong-gu, Daejeon, 305-701 (Republic of Korea), Fax: (+82) 42-350-3910
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  • This work was supported by Korean Ministry of Environment as “The Eco-Technopia 21” project.

Abstract

original image

Don′t FRET when I GO: Sensitive and selective rotavirus detection is achieved by using the photoluminescence of a graphene oxide (GO) array. The target cell was captured by the rotavirus-specific antibody immobilized on the GO array, and the binding event was monitored by observing the fluorescence quenching that results from fluorescence resonance energy transfer (FRET) between GO and gold nanoparticles linked to the antibodies (see picture).

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