Communication

Discrimination of Human Astrocytoma Subtypes by Lipid Analysis Using Desorption Electrospray Ionization Imaging Mass Spectrometry†

  1. Livia S. Eberlin1,
  2. Allison L. Dill1,
  3. Alexandra J. Golby Dr.2,
  4. Keith L. Ligon Dr.2,
  5. Justin M. Wiseman Dr.3,
  6. R. Graham Cooks Prof.1,
  7. Nathalie Y. R. Agar Dr.2

Article first published online: 2 JUL 2010

DOI: 10.1002/anie.201001452

Issue

Angewandte Chemie International Edition

Angewandte Chemie International Edition

Volume 49, Issue 34, pages 5953–5956, August 9, 2010

Additional Information

How to Cite

Eberlin, Livia S., Dill, Allison L., Golby, Alexandra J., Ligon, Keith L., Wiseman, Justin M., Cooks, R. Graham. and Agar, Nathalie Y. R. (2010), Discrimination of Human Astrocytoma Subtypes by Lipid Analysis Using Desorption Electrospray Ionization Imaging Mass Spectrometry. Angew. Chem. Int. Ed., 49: 5953–5956. doi: 10.1002/anie.201001452

Author Information

  1. 1

    Department of Chemistry and Center for Analytical Instrumentation and Development, Purdue University, West Lafayette, IN 47907 (USA), Fax: (+1) 765-494-9421

  2. 2

    Department of Neurosurgery, Department of Radiology, and Department of Medical Oncology, Brigham and Women's Hospital and Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115 (USA), Fax: (+1) 617-264-6316

  3. 3

    Prosolia, Inc., Indianapolis, IN 46202 (USA)

  1. †

    This work was supported by the U.S. National Institutes of Health (Grant 1R21EB009459-01) to L.S.E., A.L.D. and R.G.C., and by grants from the Brain Science Foundation, and the Daniel E. Ponton Fund for the Neurosciences to N.Y.R.A. Prosolia acknowledges support from the Indiana 21st Century Research and Technology Fund (J.M.W.). We gratefully acknowledge the assistance of Kristen K. Gill for tissue banking at BWH and Jessica Li of Prosolia for assistance in DESI-MS experiments.

Publication History

  1. Issue published online: 30 JUL 2010
  2. Article first published online: 2 JUL 2010
  3. Manuscript Revised: 21 APR 2010
  4. Manuscript Received: 11 MAR 2010

Funded by

  • U.S. National Institutes of Health. Grant Number: 1R21EB009459-01
  • Brain Science Foundation
  • Daniel E. Ponton Fund for the Neurosciences
  • Indiana 21st Century Research and Technology Fund

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Keywords:

  • gliomas;
  • imaging techniques;
  • molecular pathology;
  • phospholipids;
  • tissue analysis
Thumbnail image of graphical abstract

Differentiation of human brain astrocytic tumor grades can be achieved by direct lipid analysis using desorption electrospray ionization mass spectrometry (DESI-MS). Distinctive lipid profiles are associated with the degree of malignancy, grades II, III, and IV (see picture).

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