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Keywords:

  • enzyme catalysis;
  • peptides;
  • transesterification;
  • transferases;
  • tRNA mimics
Thumbnail image of graphical abstract

Natural selection: Replacement of the 3′-OH group of Ala-tRNAAla with 3′-H affected FemXWv-catalyzed aminoacyl transfer from the 2′-position, but not substrate binding. The ability of FemXWv to bind and transacylate the 3′-O-Ala isomer initially formed by alanyl-tRNA synthetase (AlaRS) may be crucial for efficient competition with the ribosome (see scheme).