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Keywords:

  • α-amino acids;
  • asymmetric catalysis;
  • binol;
  • carbenoids;
  • N[BOND]H insertion
Thumbnail image of graphical abstract

Secondary amines do it too! Catalytic asymmetric insertion of α-diazoesters in the N[BOND]H bond of differently substituted amines has been successfully achieved (see scheme; M.S.=molecular sieves). For a wide substrate scope, excellent enantioselectivities (up to 98 % ee) and high yields (up to 99 %) were obtained under mild reaction conditions.