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High-Throughput Method for Determining the Enantioselectivity of Enzyme-Catalyzed Hydroxylations Based on Mass Spectrometry

Authors


  • This work was supported by the Science & Engineering Research Council of A*STAR, Singapore, through a research grant (project No. 0621010024). J.M. thanks the China Scholarship Council for a scholarship.

Abstract

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Up to speed: An accurate, sensitive, high-throughput, and simple method for measuring the product ee value of enzyme-catalyzed hydroxylations (see scheme) is based on the use of enantiopure or enantioenriched deuterated substrates and mass spectrometric detection.

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