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Keywords:

  • deselenization;
  • desulfurization;
  • native chemical ligation;
  • peptides;
  • protein modification
Thumbnail image of graphical abstract

Selective deselenization: Native chemical ligation at selenocysteine is followed by selective deselenization of the selenocysteine to alanine, in the presence of cysteine residues without protecting groups (see scheme). This selectivity is achieved by using the water-soluble tris(2-carboxyethyl)phosphine (TCEP) in the absence of a radical initiator.