The author thanks the Deutsche Forschungsgemeinschaft (SFB 803 “Functionality controlled by organization in and between membranes”) and the Fonds der Chemischen Industrie (Sachkostenzuschuss) for financial support.
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Convergence Leads to Success: Total Synthesis of the Complex Nonribosomal Peptide Polytheonamide B†
Article first published online: 22 JUN 2010
DOI: 10.1002/anie.201001917
Copyright © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
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How to Cite
Ducho, C. (2010), Convergence Leads to Success: Total Synthesis of the Complex Nonribosomal Peptide Polytheonamide B. Angew. Chem. Int. Ed., 49: 5034–5036. doi: 10.1002/anie.201001917
- †
Publication History
- Issue published online: 7 JUL 2010
- Article first published online: 22 JUN 2010
- Manuscript Received: 31 MAR 2010
Funded by
- Deutsche Forschungsgemeinschaft
- Fonds der Chemischen Industrie
- Abstract
- Article
- References
- Cited By
Keywords:
- amino acids;
- ion channels;
- peptides;
- peptide synthesis;
- sulfoxides
Beyond the ribosome: The highly cytotoxic 48 residue nonribosomal peptide polytheonamide B, proposed to act as an ion channel, was synthesized by the coupling of four building blocks. The assembly of these peptide segments required the synthesis of eight nonproteinogenic amino acids, including a unique sulfoxide. This first synthetic route towards polytheonamide B (see scheme) demonstrates the potential of state-of-the-art peptide chemistry.