Vitamin B12 Mimics Having a Peptide Backbone and Tuneable Coordination and Redox Properties


  • We thank R. Alberto, A. Eschenmoser, T. Fox, and O. Zerbe for helpful discussions and L. Bigler for recording the HR-ESI-MS spectra. A generous gift of vitamin B12 from DSM Nutritional Products AG (Basel/Switzerland) is acknowledged. This work was supported by the Swiss National Science Foundation (grant no. 200021-117822).


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A fortified vitamin: A new class of vitamin B12 mimics with a peptide backbone has been developed (see structure). The choice of an appropriate linker between the corrin macrocycle and the dimethylbenzimidazole base makes it possible to modulate selectively the coordination and redox properties at the metal center.