The Driving Mechanism Behind Attrition-Enhanced Deracemization

Authors


  • The SNN agency (Cooperation Northern Netherlands) and the European Fund for Regional Development (EFRO) are acknowledged for partial financial support of this work. The group from Radboud University Nijmegen thanks COST Action CM0703 for support.

Abstract

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Change of heart: A solution-phase enantiomeric excess that has the handedness of the minor population of the solid phase is observed during grinding of a slurry of racemic conglomerate crystals. This excess is the driving force for a net flux of molecules from crystals of the minor handedness to crystals of the major handedness, thus explaining the complete deracemization of the solid phase (see picture: blue: S form, red: R form).

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