This research was supported financially by the Deutsche Forschungsgemeinschaft (research unit FOR630 “Biological Function of Organometallic Compounds”).
Metal Complexes as Protein Kinase Inhibitors†
Article first published online: 29 JUN 2010
Copyright © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 49, Issue 31, pages 5226–5227, July 19, 2010
How to Cite
Kunick, C. and Ott, I. (2010), Metal Complexes as Protein Kinase Inhibitors. Angew. Chem. Int. Ed., 49: 5226–5227. doi: 10.1002/anie.201002062
- Issue published online: 16 JUL 2010
- Article first published online: 29 JUN 2010
- Manuscript Received: 7 APR 2010
- Deutsche Forschungsgemeinschaft
- bioorganometallic chemistry;
- N ligands
Angiogenesis inhibition: Metal complexes are often overlooked in the development of new drugs. However, rationally designed iridium complexes with bidentate pyridocarbazole ligands have been found to act as selective protein kinase inhibitors. Experiments in zebrafish embryos revealed impressive anti-angiogenic effects for this type of metallodrug. (Picture: tumor-induced angiogenesis in a zebrafish embryo; red: transplanted tumor cells, green: blood vessels).