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Keywords:

  • asymmetric catalysis;
  • fluorine;
  • heterocycles;
  • organocatalysis;
  • phase-transfer catalysis
Thumbnail image of graphical abstract

Cuts both ways: The title reaction consists of an addition/cyclization/dehydration sequence and affords the biologically important chiral 3,5-diaryl-5-(trifluoromethyl)-2-isoxazolines 1 in excellent yields with high ee values. The flexibility of accessing either the S or R enantiomers of the products has been achieved by the appropriate choice of phase-transfer catalyst (2).