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Keywords:

  • copper;
  • Diels–Alder reaction;
  • enantioselectivity;
  • heterogeneous catalysis;
  • metalloenzymes
Thumbnail image of graphical abstract

Guided by nature: A designed binding site comprising the His/His/Asp motif for CuII complexation has been constructed in a robust protein by site-specific mutagenesis (see picture). The artificial metalloenzyme catalyzes an enantioselective Diels–Alder reaction.