This work was supported by the National Natural Science Foundation of China (20702040, 20832003, and 20972118).
Zinc Chloride Enhanced Arylations of Secondary Benzyl Trifluoroacetates in the Presence of β-Hydrogen Atoms†
Article first published online: 16 AUG 2010
Copyright © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 49, Issue 36, pages 6387–6390, August 23, 2010
How to Cite
Duan, H., Meng, L., Bao, D., Zhang, H., Li, Y. and Lei, A. (2010), Zinc Chloride Enhanced Arylations of Secondary Benzyl Trifluoroacetates in the Presence of β-Hydrogen Atoms. Angew. Chem. Int. Ed., 49: 6387–6390. doi: 10.1002/anie.201002116
- Issue published online: 19 AUG 2010
- Article first published online: 16 AUG 2010
- Manuscript Received: 9 APR 2010
- National Natural Science Foundation of China. Grant Numbers: 20702040, 20832003, 20972118
- CC coupling;
Zinc or swim: Arylation of benzyl trifluoroacetates with arylzinc reagents in the presence of β-hydrogen atoms were realized under mild conditions. Both electron-rich and electron-deficient arene substrates were successfully arylated. This arylation method could offer a very versatile synthetic route to access a series of diversity-oriented diarylalkane motifs. TFA = trifluoroacetyl.