Zinc Chloride Enhanced Arylations of Secondary Benzyl Trifluoroacetates in the Presence of β-Hydrogen Atoms


  • This work was supported by the National Natural Science Foundation of China (20702040, 20832003, and 20972118).


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Zinc or swim: Arylation of benzyl trifluoroacetates with arylzinc reagents in the presence of β-hydrogen atoms were realized under mild conditions. Both electron-rich and electron-deficient arene substrates were successfully arylated. This arylation method could offer a very versatile synthetic route to access a series of diversity-oriented diarylalkane motifs. TFA = trifluoroacetyl.