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Palladium-Catalyzed Coupling Reactions: Carbonylative Heck Reactions To Give Chalcones

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  • We thank the State of Mecklenburg-Vorpommern and the Bundesministerium für Bildung und Forschung (BMBF) for financial support. We also thank S. Leiminger, K. Mevius, Dr. W. Baumann, Dr. C. Fischer, and S. Buchholz (LIKAT) for analytical support and S. Leiminger for technical assistance.

Abstract

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Chalcones made easy: Carbonylative Heck reactions of aryl and alkenyl triflate derivatives with carbon monoxide and aromatic olefins proceed in the presence of palladium catalysts (see scheme; dppp=1,3-bis(diphenylphosphino)propane, Tf=triflate; R=aryl, vinyl). With this process, the gap between the Suzuki and Sonogashira carbonylative reactions is finally bridged.

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