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Keywords:

  • bioconjugation;
  • hydrazones;
  • metalloenzymes;
  • phosphanes;
  • rhodium
Thumbnail image of graphical abstract

A joint effort: A novel, highly efficient, and selective procedure for phosphane modification of proteins is reported (see scheme). This method involves cysteine modification with a maleimide containing a hydrazide functional group and subsequent hydrazone formation with phosphane aldehydes. Mono- and bidentate phosphane ligands were successfully coupled to several proteins, one of which was coordinated to rhodium to give an artificial metalloenzyme.