These authors contributed equally.
Conformational Switching of G-Quadruplex DNA by Photoregulation†
Article first published online: 22 JUN 2010
Copyright © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 49, Issue 31, pages 5305–5309, July 19, 2010
How to Cite
Wang, X., Huang, J., Zhou, Y., Yan, S., Weng, X., Wu, X., Deng, M. and Zhou, X. (2010), Conformational Switching of G-Quadruplex DNA by Photoregulation. Angew. Chem. Int. Ed., 49: 5305–5309. doi: 10.1002/anie.201002290
We thank Prof. Guangfu Yang (College of Chemistry, Central China Normal University, Hubei, Wuhan) for providing Accelrys Discovery Studio 2.1 software. X.Z. thanks the NSFC (National Science Fund of China, No. 90813031, 30973605) and the National Key Foundation for Infectious Diseases (protection against and treatment of AIDS and hepatitis, 2008ZX10003-005).
- Issue published online: 16 JUL 2010
- Article first published online: 22 JUN 2010
- Manuscript Received: 18 APR 2010
- NSFC. Grant Numbers: 90813031, 30973605
- National Key Foundation for Infectious Diseases. Grant Number: 2008ZX10003-005
- circular dichroism;
Bend and stretch… bend and stretch… An azobenzene derivative was used to induce reversible stretching and folding of G-quadruplex DNA upon photoirradiation (see picture). The G quadruplex formed in the presence of the trans isomer was dissociated by irradiation with UV light, and the resulting open oligomer was refolded into a G quadruplex under visible light. This nanodevice thus converts light directly into mechanical work.