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Conformational Switching of G-Quadruplex DNA by Photoregulation

Authors

  • Xiaolin Wang,

    1. College of Chemistry and Molecular Sciences, Key Laboratory of Biomedical Polymers, Ministry of Education, Wuhan University, Hubei, Wuhan 430072 (P.R. China), Fax: (+86) 27-8733-6380
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    • These authors contributed equally.

  • Jing Huang,

    1. College of Chemistry and Molecular Sciences, Key Laboratory of Biomedical Polymers, Ministry of Education, Wuhan University, Hubei, Wuhan 430072 (P.R. China), Fax: (+86) 27-8733-6380
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    • These authors contributed equally.

  • Yangyang Zhou,

    1. College of Chemistry and Molecular Sciences, Key Laboratory of Biomedical Polymers, Ministry of Education, Wuhan University, Hubei, Wuhan 430072 (P.R. China), Fax: (+86) 27-8733-6380
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  • Shengyong Yan,

    1. College of Chemistry and Molecular Sciences, Key Laboratory of Biomedical Polymers, Ministry of Education, Wuhan University, Hubei, Wuhan 430072 (P.R. China), Fax: (+86) 27-8733-6380
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  • Xiaocheng Weng,

    1. College of Chemistry and Molecular Sciences, Key Laboratory of Biomedical Polymers, Ministry of Education, Wuhan University, Hubei, Wuhan 430072 (P.R. China), Fax: (+86) 27-8733-6380
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  • Xiaojun Wu,

    1. College of Chemistry and Molecular Sciences, Key Laboratory of Biomedical Polymers, Ministry of Education, Wuhan University, Hubei, Wuhan 430072 (P.R. China), Fax: (+86) 27-8733-6380
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  • Minggang Deng,

    1. College of Chemistry and Molecular Sciences, Key Laboratory of Biomedical Polymers, Ministry of Education, Wuhan University, Hubei, Wuhan 430072 (P.R. China), Fax: (+86) 27-8733-6380
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  • Xiang Zhou Prof.

    1. College of Chemistry and Molecular Sciences, Key Laboratory of Biomedical Polymers, Ministry of Education, Wuhan University, Hubei, Wuhan 430072 (P.R. China), Fax: (+86) 27-8733-6380
    2. State Key Laboratory of Natural and Biomimetic Drugs, Peking University and State Key Laboratory of Applied Organic Chemistry, Lanzhou University (P.R. China)
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  • We thank Prof. Guangfu Yang (College of Chemistry, Central China Normal University, Hubei, Wuhan) for providing Accelrys Discovery Studio 2.1 software. X.Z. thanks the NSFC (National Science Fund of China, No. 90813031, 30973605) and the National Key Foundation for Infectious Diseases (protection against and treatment of AIDS and hepatitis, 2008ZX10003-005).

Abstract

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Bend and stretch… bend and stretch… An azobenzene derivative was used to induce reversible stretching and folding of G-quadruplex DNA upon photoirradiation (see picture). The G quadruplex formed in the presence of the trans isomer was dissociated by irradiation with UV light, and the resulting open oligomer was refolded into a G quadruplex under visible light. This nanodevice thus converts light directly into mechanical work.

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