Nanoparticle Supracrystals and Layered Supracrystals as Chemical Amplifiers


  • This work was supported by the Non-equilibrium Energy Research Center (NERC), which is an Energy Frontier Research Center funded by the U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences under Award Number DE-SC0000989.


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Seeing is believing: Nanoparticle crystals and core–shell crystals detect and amplify the presence of chemical and enzymatic analytes. These crystals are made insoluble in water by cross-linking their surface with dithiols incorporating analyte-specific groups. Upon addition of an analyte, these groups are cut, and the “punctured” crystals liberate millions of individual, brightly colored NPs (see picture).