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Catalytic Organometallic Reactions of Ammonia

Authors

  • Jessica L. Klinkenberg,

    1. Department of Chemistry, University of Illinois, Urbana-Champaign, 600 S. Mathews Ave, Urbana, IL 61801 (USA), Fax: (+1) 217-244-9248
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  • Prof. John F. Hartwig

    Corresponding author
    1. Department of Chemistry, University of Illinois, Urbana-Champaign, 600 S. Mathews Ave, Urbana, IL 61801 (USA), Fax: (+1) 217-244-9248
    • Department of Chemistry, University of Illinois, Urbana-Champaign, 600 S. Mathews Ave, Urbana, IL 61801 (USA), Fax: (+1) 217-244-9248
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Abstract

Until recently, ammonia had rarely succumbed to catalytic transformations with homogeneous catalysts, and the development of such reactions that are selective for the formation of single products under mild conditions has encountered numerous challenges. However, recently developed catalysts have allowed several classes of reactions to create products with nitrogen-containing functional groups from ammonia. These reactions include hydroaminomethylation, reductive amination, alkylation, allylic substitution, hydroamination, and cross-coupling. This Minireview describes examples of these processes and the factors that control catalyst activity and selectivity.

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