Direct Amination of Secondary Alcohols Using Ammonia


  • We would like to thank Ton Staring for his technical assistance. This research has been funded by the Netherlands Ministry of Economic Affairs and the Netherlands Ministry of Education, Culture, and Sciences within the framework of the CatchBio program. C. M. thanks the Netherlands Organization for Scientific Research (NWO-CW) for financial support.


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Hydrogen shuttle: For the first time secondary alcohols and ammonia can be directly converted into primary amines with a selectivity of up to 99 % by using a simple ruthenium/phosphine catalyst (see scheme; R1, R2= alkyl, aryl, alkenyl; M=[Ru3(CO)12]; and L=phosphine ligand).