We thank Novartis AG for support of this work as well the staff of the MIT Microsystems Technology Laboratories for assistance with microfabrication, and Corning for generously providing an Advanced-Flow Glass Reactor.
An Integrated Microreactor System for Self-Optimization of a Heck Reaction: From Micro- to Mesoscale Flow Systems†
Article first published online: 19 AUG 2010
Copyright © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 49, Issue 39, pages 7076–7080, September 17, 2010
How to Cite
McMullen, J. P., Stone, M. T., Buchwald, S. L. and Jensen, K. F. (2010), An Integrated Microreactor System for Self-Optimization of a Heck Reaction: From Micro- to Mesoscale Flow Systems. Angew. Chem. Int. Ed., 49: 7076–7080. doi: 10.1002/anie.201002590
- Issue published online: 14 SEP 2010
- Article first published online: 19 AUG 2010
- Manuscript Received: 30 APR 2010
- CC coupling;
- synthetic methods
Set it and forget it: The combination of feedback control and continuous-flow operations in microreactors (see picture) enables online and fully automated reaction optimization. A Heck reaction demonstrates the potential for rapid multivariable reaction optimization while requiring a minimal amount of material. Optimal conditions are quickly scaled-up by a factor of 50.