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Keywords:

  • arenes;
  • C[BOND]C coupling;
  • microreactors;
  • palladium;
  • synthetic methods
Thumbnail image of graphical abstract

Set it and forget it: The combination of feedback control and continuous-flow operations in microreactors (see picture) enables online and fully automated reaction optimization. A Heck reaction demonstrates the potential for rapid multivariable reaction optimization while requiring a minimal amount of material. Optimal conditions are quickly scaled-up by a factor of 50.