An Integrated Microreactor System for Self-Optimization of a Heck Reaction: From Micro- to Mesoscale Flow Systems


  • We thank Novartis AG for support of this work as well the staff of the MIT Microsystems Technology Laboratories for assistance with microfabrication, and Corning for generously providing an Advanced-Flow Glass Reactor.


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Set it and forget it: The combination of feedback control and continuous-flow operations in microreactors (see picture) enables online and fully automated reaction optimization. A Heck reaction demonstrates the potential for rapid multivariable reaction optimization while requiring a minimal amount of material. Optimal conditions are quickly scaled-up by a factor of 50.