This work was supported by the National Institutes of Health (U54 CA119341).
An Inhibitor of a Cell Adhesion Receptor Stimulates Cell Migration†
Article first published online: 9 SEP 2010
Copyright © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 49, Issue 42, pages 7706–7709, October 11, 2010
How to Cite
Shabbir, S. H., Eisenberg, J. L. and Mrksich, M. (2010), An Inhibitor of a Cell Adhesion Receptor Stimulates Cell Migration . Angew. Chem. Int. Ed., 49: 7706–7709. doi: 10.1002/anie.201002699
- Issue published online: 8 OCT 2010
- Article first published online: 9 SEP 2010
- Manuscript Received: 4 MAY 2010
- National Institutes of Health. Grant Number: U54 CA119341
- cell adhesion;
- polyvalent interactions;
- self-assembled monolayers
Making cells get a move on: The integrins are cell-surface receptors that mediate the adhesion and migration of cells on a protein matrix. An open question is whether addition of an inhibitor of the receptor slows or accelerates cell migration. By using self-assembled monolayers presenting a cell adhesion ligand as a model system it is found that an inhibitor (RGD peptide) can stimulate cell migration.