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Keywords:

  • cell adhesion;
  • inhibitors;
  • integrin;
  • polyvalent interactions;
  • self-assembled monolayers
Thumbnail image of graphical abstract

Making cells get a move on: The integrins are cell-surface receptors that mediate the adhesion and migration of cells on a protein matrix. An open question is whether addition of an inhibitor of the receptor slows or accelerates cell migration. By using self-assembled monolayers presenting a cell adhesion ligand as a model system it is found that an inhibitor (RGD peptide) can stimulate cell migration.