Polyfluorophores on a DNA Backbone: Sensors of Small Molecules in the Vapor Phase


  • We thank the US National Institutes of Health (GM067201) for support. F.S. acknowledges a fellowship from the Swiss National Science Foundation. Y.N.T. acknowledges an A*STAR fellowship. We thank Dr. N. Dai for contributing to the synthesis of monomers.


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With a response for any occasion: Oligodeoxyfluorosides (ODFs) conjugated to poly(ethylene glycol)–polystyrene beads were used as fluorescent sensors of multiple organic vapors (see picture). The ODFs—DNA-like oligomers in which fluorophores, spacers, and quencher groups replace DNA bases—had sufficient electronic diversity to show a wide range of responses to chemically varied volatile organic compounds.