Financial support by the German research foundation (DFG, FOR 474) is gratefully acknowledged. We thank Membrana GmbH for provision of the oxygenator fiber membranes.
Continuous 1H and 13C Signal Enhancement in NMR Spectroscopy and MRI Using Parahydrogen and Hollow-Fiber Membranes†
Article first published online: 29 OCT 2010
Copyright © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 49, Issue 45, pages 8358–8362, November 2, 2010
How to Cite
Roth, M., Kindervater, P., Raich, H.-P., Bargon, J., Spiess, H. W. and Münnemann, K. (2010), Continuous 1H and 13C Signal Enhancement in NMR Spectroscopy and MRI Using Parahydrogen and Hollow-Fiber Membranes. Angew. Chem. Int. Ed., 49: 8358–8362. doi: 10.1002/anie.201002725
- Issue published online: 29 OCT 2010
- Article first published online: 29 OCT 2010
- Manuscript Received: 5 MAY 2010
- DFG. Grant Number: FOR 474
- chemical selectivity;
- NMR spectroscopy;
- polarization transfer
Parahydrogen-induced polarization is used for the continuous generation of hyperpolarized molecules. Constant 1H and 13C NMR signal enhancement is demonstrated using a continuous delivery of parahydrogen by hollow fiber membranes (see picture, left), which allows the acquisition of two-dimensional NMR signals requiring multiple acquisitions with constant initial polarization.