Financial support by the German research foundation (DFG, FOR 474) is gratefully acknowledged. We thank Membrana GmbH for provision of the oxygenator fiber membranes.
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Communication
Continuous 1H and 13C Signal Enhancement in NMR Spectroscopy and MRI Using Parahydrogen and Hollow-Fiber Membranes†
Article first published online: 29 OCT 2010
DOI: 10.1002/anie.201002725
Copyright © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Roth, M., Kindervater, P., Raich, H.-P., Bargon, J., Spiess, H. W. and Münnemann, K. (2010), Continuous 1H and 13C Signal Enhancement in NMR Spectroscopy and MRI Using Parahydrogen and Hollow-Fiber Membranes. Angew. Chem. Int. Ed., 49: 8358–8362. doi: 10.1002/anie.201002725
- †
Publication History
- Issue published online: 29 OCT 2010
- Article first published online: 29 OCT 2010
- Manuscript Received: 5 MAY 2010
Funded by
- DFG. Grant Number: FOR 474
Keywords:
- chemical selectivity;
- hyperpolarization;
- NMR spectroscopy;
- parahydrogen;
- polarization transfer
Parahydrogen-induced polarization is used for the continuous generation of hyperpolarized molecules. Constant 1H and 13C NMR signal enhancement is demonstrated using a continuous delivery of parahydrogen by hollow fiber membranes (see picture, left), which allows the acquisition of two-dimensional NMR signals requiring multiple acquisitions with constant initial polarization.