Continuous 1H and 13C Signal Enhancement in NMR Spectroscopy and MRI Using Parahydrogen and Hollow-Fiber Membranes


  • Financial support by the German research foundation (DFG, FOR 474) is gratefully acknowledged. We thank Membrana GmbH for provision of the oxygenator fiber membranes.


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Parahydrogen-induced polarization is used for the continuous generation of hyperpolarized molecules. Constant 1H and 13C NMR signal enhancement is demonstrated using a continuous delivery of parahydrogen by hollow fiber membranes (see picture, left), which allows the acquisition of two-dimensional NMR signals requiring multiple acquisitions with constant initial polarization.