Cross-Coupling in a Flow Microreactor: Space Integration of Lithiation and Murahashi Coupling


  • This work was partially supported by the Grant-in-Aid for Scientific Research and NEDO projects.


original image

Going with the flow: The use of palladium catalysts bearing a carbene ligand resulted in a faster Murahashi coupling, and enabled its integration with the Br–Li exchange of ArBr with BuLi in a microreactor (see picture). This system allows the cross-coupling of two different aryl bromides within a minute without necessitating low temperatures (−78°C).