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Multifunctional Gold Nanoshells on Silica Nanorattles: A Platform for the Combination of Photothermal Therapy and Chemotherapy with Low Systemic Toxicity


  • We thank Prof. Jing Liu for use of the infrared thermal mapping apparatus. This work was supported by the National Hi-Tech Research and Development Program (863 Program) of China (Nos. 2009AA03z322, 2007AA021802, and 2007AA021803) and the National Natural Science Foundation of China (Nos. 60736001, 30800258, and 20873171).


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Magic bullets: A drug-loaded structure comprising a PEGylated (PEG=polyethylene glycol) gold nanoshell on silica nanorattle spheres (GSNs; see picture) combines remote-controlled photothermal therapy with chemotherapy. Tumor cells are killed with higher efficacy and less toxicity than the free drug.