Role of the Conformational Rigidity in the Design of Biomimetic Antimicrobial Compounds


  • We thank A. Antipova for her help with the monolayer experiments. D.G. is supported by the NIH (R01 AI073892) and DARPA (W911NF-09-1-378). A.M. is supported by the Israel Science Foundation (grant no. 283/08). ChemMatCARS Sector 15 is principally supported by the National Science Foundation Department of Energy (NSF/CHE-0822838). Use of the Advanced Photon Source was supported by the U. S. Department of Energy, Office of Science, Office of Basic Energy Sciences, under contract no. DE-AC02-06CH11357.


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When structural flexibility is a plus: A link between structural flexibility of biomimetic antimicrobials and their ability to penetrate into the hydrophobic core and disrupt the integrity of bacterial lipid model membranes has been established using liquid surface X-ray scattering techniques. Results indicate that the modes of interaction of flexible and conformationally restrained antimicrobials with the bacterial membranes are different (see picture).