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Enantioselective Halocyclization Reactions for the Synthesis of Chiral Cyclic Compounds


  • Financial support from the Major State Basic Research and Development Program (2006CB806105) and the National Natural Science Foundation of China (20732005) for our research in a related area is appreciated.


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Ground-breaking progress has been made in the synthesis of chiral cyclic compounds from nonchiral unsaturated substrates with a nucleophilic functionality. A number of highly enantioselective electrophilic halocyclizations based on either the interaction of a chiral Lewis acid with an unsaturated substrate or the generation of a chiral electrophilic intermediate in situ from an electrophile and a chiral reagent (see scheme) were developed.