These authors contributed equally.
An Unusual Galactofuranose Lipopolysaccharide That Ensures the Intracellular Survival of Toxin-Producing Bacteria in Their Fungal Host†
Article first published online: 17 AUG 2010
Copyright © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 49, Issue 41, pages 7476–7480, October 4, 2010
How to Cite
Leone, M. R., Lackner, G., Silipo, A., Lanzetta, R., Molinaro, A. and Hertweck, C. (2010), An Unusual Galactofuranose Lipopolysaccharide That Ensures the Intracellular Survival of Toxin-Producing Bacteria in Their Fungal Host. Angew. Chem. Int. Ed., 49: 7476–7480. doi: 10.1002/anie.201003301
We thank the JCVI Annotation Service for providing us with automatic annotation data and the manual annotation tool Manatee, K. Graupner for PCR screening of mutants, L. Sturiale for MS spectra, and G.-M. Schwinger for fungal-strain maintenance. This research was supported by the graduate school of excellence ILRS/JSMC (C.H.) and by PRIN MIUR 2007/2008 (R.L. and A.M.).
- Issue published online: 29 SEP 2010
- Article first published online: 17 AUG 2010
- Manuscript Received: 31 MAY 2010
- PRIN MIUR 2007/2008
- cell recognition;
- O antigens
Dress code for living in a fungus: Analysis of the carbohydrate coating of the toxin-producing endobacterium of the phytopathogenic fungus Rhizopus microsporus revealed an unprecedented lipopolysaccharide (LPS) structure, which is important for infection and colonization of the fungal host. A mutant lacking the unusual [2)-β-D-galactofuranose-(1]n O antigen (red in the schematic illustration) was incapable of forming a stable symbiosis with the fungus.