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Keywords:

  • azides;
  • phosphoramidites;
  • RNA;
  • solid-phase synthesis;
  • tRNA
Thumbnail image of graphical abstract

Flexibility exercised: Hydrolysis-resistant 3′-aminoacyl-tRNA conjugates that contain a stable amide linkage instead of the natural ester are valuable substrates for biochemical studies of ribosomal processes. In a novel preparation of the stable E. coli initiator tRNA derivative 3′-(N-formylmethionyl)amino-tRNAfMet the key feature is the synthesis of 3′-azido oligoribonucleotides using a new functionalized solid support.