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Effects of Neighboring Glycans on Antibody–Carbohydrate Interaction

Authors

  • Dr. Chi-Hui Liang,

    1. The Genomics Research Center, Academia Sinica, Taiwan, 128 Academia Road, Section 2, Nankang, Taipei 115 (Taiwan)
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    • These authors contributed equally.

  • Dr. Sheng-Kai Wang,

    1. Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA)
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    • These authors contributed equally.

  • Chin-Wei Lin,

    1. The Genomics Research Center, Academia Sinica, Taiwan, 128 Academia Road, Section 2, Nankang, Taipei 115 (Taiwan)
    2. Chemical Biology and Molecular Biophysics, Taiwan International Graduate Program, Academia Sinica, 128 Academia Road, Section 2, Nankang, Taipei 115 (Taiwan)
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  • Dr. Cheng-Chi Wang,

    1. Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA)
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  • Prof. Chi-Huey Wong,

    Corresponding author
    1. The Genomics Research Center, Academia Sinica, Taiwan, 128 Academia Road, Section 2, Nankang, Taipei 115 (Taiwan)
    2. Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA)
    3. Chemical Biology and Molecular Biophysics, Taiwan International Graduate Program, Academia Sinica, 128 Academia Road, Section 2, Nankang, Taipei 115 (Taiwan)
    • The Genomics Research Center, Academia Sinica, Taiwan, 128 Academia Road, Section 2, Nankang, Taipei 115 (Taiwan)
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  • Prof. Chung-Yi Wu

    Corresponding author
    1. The Genomics Research Center, Academia Sinica, Taiwan, 128 Academia Road, Section 2, Nankang, Taipei 115 (Taiwan)
    2. Chemical Biology and Molecular Biophysics, Taiwan International Graduate Program, Academia Sinica, 128 Academia Road, Section 2, Nankang, Taipei 115 (Taiwan)
    • The Genomics Research Center, Academia Sinica, Taiwan, 128 Academia Road, Section 2, Nankang, Taipei 115 (Taiwan)
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  • This work was supported by Academia Sinica and the National Science Council, Taiwan (grant no. NSC-97-2113M001-009-MY2 to C.-Y.W).

Abstract

original image

Who can? Glycan! Heterogeneous glycan microarrays were prepared for the study of antibody binding specificity and affinity. It was found that heterogeneous glycans provide better binding affinity compared to their individual components (see picture), thereby suggesting a new strategy for carbohydrate-based vaccine design.

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