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Trapping Unstable Benzoquinone Analogues by Coordination to a [(η5-C5Me5)Ir] Fragment and the Anticancer Activity of the Resulting Complexes


  • Our studies in bioorganometallic chemistry are funded by the University of Vienna, the Johanna Mahlke (geb. Obermann) Foundation, the Hochschuljubiläumsstiftung Vienna, the Austrian Research Promotion Agency (811591), the Austrian Council for Research and Technology Development (IS526001), the Higher Education Commission of Pakistan, the Austrian Exchange Service (ÖAD), COST D39, CM0902), and the Austrian Science Fund.


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Gotcha! Unstable dithio- and diselenobenzoquinones can be trapped by coordination to an [(η5-C5Me5)Ir] moiety (see structure; gray C, white H, pink Ir, yellow Se). In vitro investigations on the anticancer activity of the resulting complexes showed them to be comparable to cis-platin. These organometallic species could form the basis for new anticancer agents.