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Keywords:

  • immobilized metal ion affinity chromatography;
  • magnetic properties;
  • mass spectrometry;
  • mesoporous materials;
  • peptides
Thumbnail image of graphical abstract

Captivating pores: Copper ions were immobilized on mesoporous silica shells with perpendicularly aligned pore channels, formed on Fe3O4 cores through a surfactant-templated sol–gel process. The highly accessible mesopores, large in-pore surface, and numerous Cu2+ ions on the microspheres allowed selective capture of hydrophobic and hydrophilic peptides from complex biosamples followed by magnetic separation and MS analysis (see picture).