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Reversible pH-Regulated Control of Photosensitized Singlet Oxygen Production Using a DNA i-Motif


  • The work was supported by the Danish National Research Foundation.


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On again, off again: Reversible pH-controlled on-and-off switching of a singlet oxygen sensitizer is achieved when an i-motif DNA sequence is employed to control the proximity of a singlet oxygen sensitizer and a quencher (see picture). At pH values less than 5, the i-motif is stable and the singlet oxygen sensitizer quenched, whereas at pH values above 8 the i-motif is denatured and singlet oxygen production is increased by a factor of 35.