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Total Chemical Synthesis of Di-ubiquitin Chains


  • This work was supported by the Edmond J. Safra Foundation.


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Building the chains: A general and effective approach for the total chemical synthesis of all the di-ubiquitin chains (see picture) is presented. The behavior of the synthetic chains in the presence of isopeptidase T, an enzyme responsible for the disassembly of the majority of unanchored polyubiquitin in vivo, was examined.

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