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We are indebted to the computer resources provided by the Barcelona Supercomputing Center. This work was supported by BIO2009-10964, Consolider E-science and COMBIOMED ISCIII projects, and the Fundación Marcelino Botin. The authors thank Profs. F. J. Luque and V. Muñoz for critical comments.
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Communication
Multiple Routes to Characterize the Folding of a Small DNA Hairpin†
Article first published online: 15 SEP 2010
DOI: 10.1002/anie.201003816
Copyright © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Portella, G. and Orozco, M. (2010), Multiple Routes to Characterize the Folding of a Small DNA Hairpin. Angew. Chem. Int. Ed., 49: 7673–7676. doi: 10.1002/anie.201003816
- †
Publication History
- Issue published online: 8 OCT 2010
- Article first published online: 15 SEP 2010
- Manuscript Received: 22 JUN 2010
Funded by
- BIO2009-10964
- Consolider E-science
- COMBIOMED ISCIII
- Fundación Marcelino Botin
Keywords:
- computational biophysics;
- DNA;
- hairpin folding;
- molecular dynamics
DNA perming: Folding of a small DNA hairpin from an extended conformation follows two main folding pathways: direct folding (green arrows) and de-trapping from non-native compact structures (red arrows). (Also shown: guanosine 5′G anti form.)