Copper-Catalyzed Direct Carboxylation of C[BOND]H Bonds with Carbon Dioxide

Authors

  • Dr. Liang Zhang,

    1. Organometallic Chemistry Laboratory and Advanced Catalyst Research Team, RIKEN Advanced Science Institute, 2-1 Hirosawa, Wako, Saitama 351-0198 (Japan), Fax: (+81) 48-462-4665
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  • Dr. Jianhua Cheng,

    1. Organometallic Chemistry Laboratory and Advanced Catalyst Research Team, RIKEN Advanced Science Institute, 2-1 Hirosawa, Wako, Saitama 351-0198 (Japan), Fax: (+81) 48-462-4665
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  • Dr. Takeshi Ohishi,

    1. Organometallic Chemistry Laboratory and Advanced Catalyst Research Team, RIKEN Advanced Science Institute, 2-1 Hirosawa, Wako, Saitama 351-0198 (Japan), Fax: (+81) 48-462-4665
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  • Prof. Dr. Zhaomin Hou

    1. Organometallic Chemistry Laboratory and Advanced Catalyst Research Team, RIKEN Advanced Science Institute, 2-1 Hirosawa, Wako, Saitama 351-0198 (Japan), Fax: (+81) 48-462-4665
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  • Financial support from the Japan Society for the Promotion of Science (JSPS) is gratefully acknowledged. L.Z. thanks JSPS for a postdoctoral fellowship.

Abstract

original image

Cooking with gas: Copper complexes serve as excellent catalysts for the direct carboxylation of aromatic heterocyclic C[BOND]H bonds with CO2, thereby offering an economical and environmentally benign process for the synthesis of heterocyclic carboxylic esters (see scheme; IPr=1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene). Some active intermediates of this reaction have been isolated and structurally characterized.

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